John T O'Brien Selected Research

Lewy Body Disease (Lewy Body Dementia)

1/2022	The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.
1/2022	Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.
10/2021	Uniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.
1/2021	Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.
1/2021	Hippocampal and insula volume in mild cognitive impairment with Lewy bodies.
10/2020	Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease.
1/2020	EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease.
6/2019	123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.
1/2018	Non-pharmacological interventions for Lewy body dementia: a systematic review.
1/2018	A new visual rating scale for Ioflupane imaging in Lewy body disease.

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John T O'Brien Research Topics

Disease

96	Dementia (Dementias) 10/2022 - 07/2002
51	Alzheimer Disease (Alzheimer's Disease) 09/2022 - 03/2002
49	Cognitive Dysfunction 09/2022 - 03/2002
29	Parkinson Disease (Parkinson's Disease) 04/2022 - 11/2004
22	Atrophy 01/2021 - 06/2004
15	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 07/2005
10	Neuroinflammatory Diseases 01/2022 - 12/2015
9	Inflammation (Inflammations) 01/2022 - 01/2005
9	Hallucinations (Hallucination) 01/2019 - 07/2005
7	Stroke (Strokes) 10/2022 - 01/2004
7	Frontotemporal Dementia (Semantic Dementia) 01/2020 - 08/2011
6	Tauopathies 01/2022 - 12/2016
6	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2017
6	Disease Progression 04/2021 - 01/2017
4	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2022 - 01/2018
4	Vascular Diseases (Vascular Disease) 05/2020 - 04/2004
4	Parkinsonian Disorders (Parkinsonism) 10/2018 - 10/2007
3	Pathologic Processes 01/2021 - 06/2004
3	Neurobehavioral Manifestations 01/2017 - 08/2011
3	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2017 - 04/2004
2	Corticobasal Degeneration 01/2022 - 01/2021
2	Synucleinopathies 01/2019 - 01/2003
2	Hypoxia (Hypoxemia) 01/2019 - 06/2006
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2018 - 12/2016
2	Encephalitis (Encephalitis, Rasmussen) 01/2017 - 10/2011
2	Movement Disorders (Movement Disorder) 08/2014 - 07/2014
2	Pain (Aches) 10/2012 - 02/2011
2	Hypertension (High Blood Pressure) 01/2011 - 08/2010
2	Memory Disorders (Memory Loss) 11/2007 - 11/2004
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	Epilepsy (Aura) 01/2019
1	Gastroparesis 01/2019
1	Asymptomatic Diseases 01/2019
1	Delirium 01/2019

Drug/Important Bio-Agent (IBA)

38	Biomarkers (Surrogate Marker)IBA 09/2022 - 10/2011
27	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2011
17	Cholinergic Agents (Cholinergics)IBA 04/2022 - 03/2005
10	LigandsIBA 12/2020 - 03/2005
10	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020 - 04/2003
10	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 06/2019 - 06/2004
9	Proteins (Proteins, Gene)FDA Link 02/2022 - 06/2006
7	SynucleinsIBA 01/2022 - 10/2011
7	Donepezil (Aricept)FDA LinkGeneric 01/2020 - 01/2007
7	Antipsychotic Agents (Antipsychotics)IBA 01/2019 - 01/2004
6	Apolipoproteins E (ApoE)IBA 11/2021 - 11/2004
6	CytokinesIBA 10/2020 - 01/2005
5	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 09/2020 - 01/2017
4	3-Iodobenzylguanidine (Iobenguane)IBA 10/2021 - 07/2017
4	Pemetrexed (MTA)FDA Link 01/2016 - 11/2007
4	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 09/2015 - 03/2005
4	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2014 - 06/2004
4	Hydrocortisone (Cortisol)FDA LinkGeneric 02/2010 - 03/2002
3	ApolipoproteinsIBA 08/2022 - 12/2011
3	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2004
3	C-Reactive ProteinIBA 01/2021 - 12/2018
3	alpha-SynucleinIBA 01/2020 - 01/2003
3	ioflupaneIBA 01/2018 - 07/2014
3	Memantine (Namenda)FDA Link 12/2017 - 08/2011
3	5-iodo-3-(2-azetidinylmethoxy)pyridineIBA 11/2016 - 04/2008
3	N 30IBA 01/2016 - 12/2014
3	HomocysteineIBA 12/2011 - 08/2010
2	Apolipoprotein E4IBA 08/2022 - 01/2021
2	FHDIBA 08/2022 - 01/2020
2	CholesterolIBA 08/2022 - 04/2004
2	Dopamine (Intropin)FDA LinkGeneric 04/2022 - 03/2009
2	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2022 - 10/2011
2	1- ((3- (methylpyridin- 4- yl)methyl)- 4- (3,4,5- trifluorophenyl)pyrrolidin- 2- oneIBA 01/2022 - 01/2020
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2021 - 01/2018
2	Fibrinogen (Factor I)FDA Link 01/2021 - 01/2019
2	PK 11195 (PK11195)IBA 12/2020 - 01/2020
2	Amyloid beta-PeptidesIBA 01/2019 - 09/2015
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 02/2016
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2017 - 08/2011
2	Rivastigmine (Exelon)FDA LinkGeneric 01/2017 - 08/2011
2	Galantamine (Galanthamine)FDA LinkGeneric 01/2017 - 08/2011
2	Vitamin E FDA LinkGeneric 01/2017 - 08/2011
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 08/2011
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 12/2014
2	Antidepressive Agents (Antidepressants)IBA 02/2015 - 10/2007
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 12/2014 - 06/2014
2	Levodopa (L Dopa)FDA LinkGeneric 10/2014 - 03/2009
2	Immunoglobulins (Immunoglobulin)IBA 05/2012 - 01/2012
2	Cell Adhesion MoleculesIBA 10/2007 - 03/2004
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 03/2004 - 01/2003
1	Coffee FDA Link 10/2022
1	Messenger RNA (mRNA)IBA 09/2022
1	Neuroprotective AgentsIBA 02/2022
1	Trazodone (Trittico)FDA LinkGeneric 02/2022
1	LipopolysaccharidesIBA 12/2021
1	Biological ProductsIBA 01/2021
1	tau Proteins (tau Protein)IBA 12/2020
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 10/2020
1	brassIBA 06/2019
1	goblet cell silencer inhibitorIBA 01/2019
1	Clozapine (Clozaril)FDA LinkGeneric 01/2019
1	cloricromen (AD 6)IBA 01/2019

Therapy/Procedure

11	Therapeutics 02/2022 - 04/2003
3	Drug Therapy (Chemotherapy) 12/2017 - 08/2011
2	Activities of Daily Living (ADL) 06/2020 - 12/2013
2	Home Nursing (Nursing, Home) 10/2012 - 02/2011